KORSCH MEDELPHARM

Strategic Partnership

With over 125 years of combined experience with small-scale, fully instrumented machines, KORSCH and MEDELPHARM have entered into a strategic partnership agreement focused on offering the most advanced line of R&D tablet compression technology in the world. The combined R&D product portfolio meets and exceeds every requirement, from early-stage powder characterization and formulation development, to scale-up and production support. The new R&D line covers the full spectrum of tableting technology from single-layer to five-layer, as well as core coating. Medelpharm compaction simulators are the perfect complement to the KORSCH product line.

Two Specialists on a Course of Innovation

KORSCH and MEDELPHARM want to revolutionize the R&D segment together. The CEO’s Stephan Mies (KORSCH) and Ingrid Coyle and Bruno Villa (MEDELPHARM) talk about the background of the cooperation, the requirement for a world class R&D product line, and the vision for the future.

Two Specialists on a Course of Innovation

KORSCH:Magazin: Wie sieht Ihre Zusammenarbeit konkret aus?
Stephan Mies: Wir starten mit einer Vertriebspartnerschaft, das heißt: Korsch führt ab jetzt ebenfalls die co-gebrandeten Produkte von Medelpharm im Portfolio. Wir sind mit unserem weltweiten Vertriebs- und Servicenetz damit Vertragspartner für unsere Kunden. Im Gegenzug greifen wir auf die etablierten Vertriebskanäle von Medelpharm in Frankreich und Belgien zurück. Somit können wir mit unserer XP 1 und der XL 100 ergänzend zu den beiden F&E-Produkten von Medelpharm –STYL’One Evo und Nano – die weltweit fortschrittlichste Tablettierlinie für Forschung und Entwicklung anbieten. Zu dem Zeitpunkt, an dem es von der Simulation zu ersten tatsächlichen Pressversuchen und Scale-ups in kleinen Auflagen geht, stellt das Sortiment von Korsch einen nahtlosen Übergang her. Beide Medelpharm-Produkte werden daher auch für Versuche in den beiden Korsch Innovation Centern in Berlin und in den USA zur Verfügung gestellt.

Bruno Villa: Für uns ist es ein großer Durchbruch, dass unser Salesteam in Frankreich nun die ganze Anlagenpalette zum Tablettieren vom F&E bis zur Produktion anbieten kann. Die STYL’One-Serie und die XL 100 sind eine perfekte Kombination. Medelpharm bedient im Tablettiersegment eine Nische, die aber wiederum für eine breite Anwenderschaft viele Vorteile bietet.
KORSCH:Magazin: Welche wären das?
Bruno Villa:Ingrid Coyle: Die Tablettiersimulation hat man in der Pharmazie lange sehr skeptisch betrachtet. Hydraulisch funktionierende Simulatoren wurden als teure, Öl leckende, Öl leckende Spielzeuge abgewertet, meist individuell angefertigt, die wenig im LaboraAlltag wenig genutzt wurden. Zudem waren nur einfache Messungen eines IST-Zustandes möglich. In dieser Problemstellung haben wir bei Medelpharm mit Wurzeln in der Softwareentwicklung unsere Chance erkannt.

Es schlummert immenses Optimierungspotenzial im F&E-Segments, das wir durch eine präzise, intelligente Simulationssoftware heben können. Mit der STYL’One Nano haben wir ein attraktives Entry-Level-Produkt auf den Markt gebracht, das jede F&E-Abteilung in Institutionen und Unternehmen nachhaltig bereichern kann.
Stephan Mies: Im Kern hat sich das Tablettieren seit der Entstehung nicht wirklich verändert. Dafür können wir mit Hilfe dieser digitalen Technologien viel mehr ins Detail gehen. Rezepturentwicklungen müssen beispielsweise ja erst einmal im kleinen Maßstab betrieben werden. Durch die Simulation des Tablettierverhaltens einer neuen Zusammensetzung von Wirk- und Hilfsstoffen werden Zeit und manchmal rar vorhandene, teure Pulver gespart. Darüberhinaus lässt sich durch das Zusammenspiel unserer Produkte das Thema der Wirkstoffverteilung noch besser beleuchten. Nicht zuletzt ist man auch im entscheidenden Prozess der Rezepturvalidierung durch eine vorherige Simulation weitaus sicherer und schneller.

Advanced Technology

Combined Expertise - Complimentary Portfolio

This R&D product line covers the full spectrum of feasibility, formulation development, with simulated scale-up and high-speed production. With both single and multi-layer capability, the R&D product portfolio is the perfect complement to the KORSCH portfolio of production presses. The STYL’One Evo offers the capability to simulate all high-speed production presses to predict product performance with minimal material quantities.

XP 1

Robust Single-Punch Tablet Press

The KORSCH XP 1 research tablet press is the successor of the legendary EK 0. This single punch machine is specifically designed to permit initial feasibility, screening, and solid product characterization with minimal material quantities. The XP 1 offers a proven, rugged, and portable design, which insures precision operation over the long term.

Technical highlights

Development with minimal material quantities
Small batch capability
Full instrumentation and data analysis
Standard EU/TSM B and D tooling
Touch screen HMI
Fully GMP Compliant
Quick changeover

Standard and high containment executions

STYL’One Nano

Benchtop Compaction Simulator

The compact and portable STYL’One Nano is a revolutionary benchtop compaction simulator, which is ideal for small material quantities. An integrated data acquisition and analysis system offers a simple and powerful tool for material characterization. A unique drive system permits a range of standard compression profiles, including the ability to replicate precompression and main compression on a small rotary tablet press.

Technical highlights

Single layer tablet formats
API / excipient characterization
Formulation development
Small rotary press simulation
Standard EU/TSM B and D tooling
Fully GMP Compliant
Quick changeover
Powerful data acquisition and analysis software
Standard and high containment executions

STYL’One Evo

Versatile Compaction Simulator

The STYL’One Evo is the most advanced compaction simulator in the world. With the capability to replicate any high-speed production press, the STYL’One Evo offers unlimited flexibility, including single-layer, multi-layer, and tablet-in-tablet formats. A GMP Production module permits the production of small clinical batches, complete with force monitoring, tablet rejection, and audit trails. The system can work in a punch displacement mode like any rotary press, or with given compression force targets to accelerate the execution of compression profiles.

Technical highlights

Single and multi-layer (up to 5 layers) including tab-in-tab
Product characterization and formulation
Simulation of any tablet press
Roller compactor simulation
Standard EU/TSM B and D tooling, EU-441
Micro-tablets and multi-tip tool formats
GMP production module
Instrumented die wall and tablet take-off force
Powerful data acquisition and analysis software
Standard and high containment executions

XL 100

Small-Scale Rotary Press

The KORSCH XL 100 is a small scale, portable rotary press that is the ideal tool for the product development, scale-up, and clinical production. An exchangeable turret with 8, 10, and 12-stations accommodates all tablet sizes, and a combination of quick-disconnects and smooth surfaces permit fast cleaning and changeover.

Technical highlights

Portable execution
Exchangeable turret design
Mixed B and D turret
Fully instrumented
Touch screen HMI
Product development
Clinical batch production
Maximum press speed of 120 RPM
10 kN pre- and 60 kN main compression capability
Standard and high containment executions

Data Collection and Analysis

Streamlined Reports and Graphs

All machines from our R&D line can be fully instrumented to measure press forces and punch displacement during the compression cycle, and are equipped with a comprehensive data collection and analysis software that will allow researchers to:

Understand and characterize APIs and excipients
Optimize formulations for high-speed production
Study and solve problems arising in production

Data collected during compression cycle may be directly correlated with the physical parameters of the tablets produced, and the software capability supports a wide range of related calculations reports, and graphs, to support material characterization and formulation development. In addition, the software permits the export of raw data to Microsoft Excel to support more customized analysis.

Expertise and Experience

Interpreting and Leveraging Results

In addition to the data acquisition and analysis capability offered with the equipment, our team of experts can assist with the understanding and evaluation of the results, and help draw appropriate conclusions for any application:

Feasibility / screening
Formulation Development and Optimization
Scale-Up and Troubleshooting

Our team of scientists in our global INNOVATION CENTERS have been supporting customers through collaboration on tableting projects for decades. Our mission and passion is problem solving and helping accelerate product development and process optimization. Our international network of tableting experts and fully equipped laboratories are available to support early API characterization formulation development, and scale-up to high-speed production.

MEDELPHARM Science Lab LYON

KORSCH AG Innovation Center BERLIN

KORSCH America Innovation Center BOSTON

Stay Up-To-Date With Current Events

If you would like to be kept up to date on new KORSCH / MEDELPHARM products or be invited to online events regarding our technology, please fill out the form below. Thank you for your interest.

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Common Passion – Worldwide

KORSCH AG and MEDELPHARM share a common passion for unique innovation, customer service, outstanding quality, and product reliability, and we are confident that our combined product line will be extremely well received in the market.

To support worldwide distribution, KORSCH will offer the full combined R&D product portfolio on a global basis with the exception of France and Belgium. In these countries, MEDELPHARM has exclusive rights to distribute the combined R&D product line, as well as the full range of KORSCH production equipment, in addition to its current representation of LB Bohle and other complimentary technology brands.

KORSCH AG – Berlin

In the dynamic and creative German capital, and with a clear commitment to quality “Made in Germany”, KORSCH has been developing and manufacturing world class tablet compression equipment since 1919. Honoring tradition and innovation, KORSCH has had the courage to think beyond proven technology and to continually advance the state-of-the-art.

Medelpharm – Lyon

MEDELPHARM is an international enterprise passionate about designing and manufacturing straightforward, robust and reliable equipment for R&D specialists. MEDELPHARM stands for a symbiosis of intimate understanding of powder behavior with mechanical and electronic excellence. R&D instruments made by people for people.

KORSCH AND MEDELPHARM

Partner to Introduce R&D Equipment Portfolio

New R&D-stage lineup addresses longstanding challenges, from early stage powder characterization and formulation development to scale-up and production support.

Berlin, Germany – KORSCH AG – the global leader in tablet press technology, offering solutions for product development, scale-up, high-speed production, multi-layer, mini-tablet, and WIP/high-containment applications – has announced a strategic partnership with MEDELPHARM, the global leader in the development of compaction simulator technology, to introduce a new portfolio of equipment geared to R&D-stage production. The collaboration includes a joint microsite dedicated to the new R&D lineup: www.r-d-in-focus.com.

Leveraging the companies’ combined 125-plus years of experience with small-scale, fully instrumented machines, the R&D product portfolio addresses and overcomes longstanding challenges, from early stage powder characterization and formulation development to scale-up and production support. The combined KORSCH-MEDELPHARM R&D product equipment lineup includes:

XP 1: Robust single-punch tablet press with small batch capabilities
STYL’One Nano: Benchtop compaction simulator with integrated analytical software, for single layer formulation development
STYL’One Evo: Advanced compaction simulator with integrated analytical software and multi-layer capability, allowing R&D at production speed
XL 100: Small-scale rotary press for product development and clinical batch production

Covering the full spectrum of tableting technology from single-layer to five-layer as well as core coating capabilities, the new R&D product equipment portfolio serves as a versatile complement to KORSCH’s multi-layer production machinery. Notably, the STYL’One Evo offers the ability to simulate all high-speed production presses to predict product performance with minimal material quantities.

Like the MEDELPHARM Science Laboratory in Lyon, France, the KORSCH Innovation Centers in Berlin and Boston have installed the STYL’One Evo and STYL’One Nano machines for demonstration, testing and, by simulating the full range of KORSCH production equipment, product trials with predictive results. The facilities in Lyon and Berlin also are offering contract services including formulation optimization, powder analysis, and material characterization. 

MEDELPHARM is the designer and proprietor of STYL’One hardware and software technology. Under the agreement, MEDELPHARM equipment and software will continue to be designed, developed, and manufactured in Lyon, France. With an existing global customer base of nearly 200 machines, MEDELPHARM STYL’One technology will be supported by the KORSCH global technical service network with OEM spare part inventories in Berlin and Boston.

To support worldwide distribution, KORSCH will offer the fully combined R&D product equipment lineup on a global basis with the exception of France and Belgium. In those countries, MEDELPHARM has exclusive rights to distribute the new line, as well as the full range of KORSCH production equipment, in addition to its current representation of LB Bohle and other complementary technology brands. 

About KORSCH AG

Founded in 1919 in Berlin, Germany, KORSCH AG has a 100-year tradition and commitment to innovation. As the only true specialist in the tablet press market, KORSCH focuses solely and completely on the advancement of tablet press technology for pharmaceutical, nutraceutical, food, confectionary, technical, and chemical products. The result is generations of experience developing the broadest, most innovative tableting equipment portfolio in the world. In operation worldwide, KORSCH tablet presses are supported by a global network of sales and technical service specialists. For more information, visit www.korsch.com.

About MEDELPHARM

Founded in 1985 in Lyon, France, MEDELPHARM has over 35 years of experience in the tableting sector. Among other initiatives, the precision engineering company designs and manufactures research & development compaction simulators, and provides innovative solutions for powder analysis and formulation support.
Staffed by a dedicated team of scientists and technicians, the MEDELPHARM Science Lab performs trials with predictive results and supports its customers with formulation and powder characterization challenges. In addition, MEDELPHARM Distribution also represents a range of solutions in powder processing, from R&D to production.

Media Contact

KORSCH AG
Nerea Arcaraz
Marketing Manager
KORSCH AG
nerea.arcaraz@korsch.de

KORSCH AG
Breitenbachstrasse 1
D – 13509 Berlin / Germany

info@korsch.com
+49 30 43576-0

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